M3536

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M3536

Sigma

 

Mycophenolic acid

powder, ≥98%, cell culture tested

Synonym:6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid
CAS Number:24280-93-1
Linear Formula:C17H20O6
Molecular Weight:320.34
Beilstein Registry Number:1295848
EC Number:246-119-3
MDL number:MFCD00036814
PubChem Substance ID:24896854

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Description

ApplicationUsed to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
 Recommended for use as a selection agent at 25 μg/ml.
Biochem/physiol ActionsMode of Action: Blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway.
 Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.

Properties

assay≥98%
formpowder
EQP levelPremium
solubilitymethanol: 50 mg/mL Stock solutions should be stored at 2-8°C.
suitabilitycell culture tested
Gene Informationhuman ... IMPDH1(3614), IMPDH2(3615)
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard CodesXn
Risk Statements61-22
Safety Statements53-45
WGK Germany3
RTECSMP8050000

References

referenceGummert, J.F., et. al. J. Pharmacol. Exp. Ther. 291, 1100-1112, (1999)
 Nimmesgern, E., et. al. J. Biol. Chem. 271, 19421-19427, (1996)
 Senda, M., et. al. Transplantation 60, 1143-1148, (1995)
MerckMerck 13,6352